CBD for Stress
In animal models of acute and chronic anxiety, CBD inhibits the endocannabinoid system’s HPA axis- and sympathetic nervous system-driven stress responses [2,3]. The anxiolytic effects of CBD are mediated by its activation of 5-HT1A receptors that reduces anxiety behaviors and the expression of fear in limbic brain regions [4,7]. CBD also modulates gamma-aminobutyric acid (GABA), which acts as a primary inhibitor in the central nervous system, preventing the release of excitatory neurotransmitters responsible for stress-related symptoms.
Anxiety disorders like social anxiety disorder, generalized anxiety disorder, panic disorder, and post-traumatic stress disorder have been shown to respond well to CBD treatment. CBD reduces the negative mood and agitation associated with these disorders, as well as the anxiety and depression that often accompany them [5,6]. This link https://www.biocbdplus.com/cbd-for-stress-all-natural-pathway-to-a-stress-free-life/
A randomized control trial using the Trier Social Stress Test in healthy participants demonstrated that CBD attenuates the acute stress-associated increase in anxiety and cortisol levels. In fact, 600 mg of CBD significantly reduced the increase in cortisol and normalized abnormally high stress responses, indicating that CBD may be useful in treating anxiety disorders.
Reducing Stress Naturally: How CBD Might Help Alleviate Your Worries
CBD’s anxiolytic effects are partially mediated by its inhibition of serotoninergic (5-HT1A) and CB2 receptor-mediated signaling, as well as its activation of peroxisome proliferator-activated receptor gamma (PPARg). The effect is potent enough to compete with the psychotropic drug clonazepam in reducing Trier-social stress test-induced anxiety and heart rate. CBD also reduces the arousal component of the stress response by acting as an indirect, non-psychotropic modulator of NMDA receptor activity.